P,P'-ddd

• [General Manufacturing Information] The WHO Recommended Classification of Pesticides by Hazard identifies DDD as an active ingredient believed to be obsolete or discontinued for use as a pesticide.
• [General Manufacturing Information] Cancellation issued prior to RPAR/Special Review Process
• [General Manufacturing Information] DDD use in the USA has been banned since the early 1970's.

Resumen de toxicidad: DDD toxicity occurs via at least four mechanisms, possibly all functioning simultaneously. DDD reduces potassium transport across the membrane. DDD inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. DDD inhibits neuronal adenosine triphosphatases (ATPases), particularly Na+K+-ATPase, and Ca2+-ATPase which play vital roles in neuronal repolarization. DDD also inhibits the ability of calmodulin, a calcium mediator in nerves, to transport calcium ions that are essential for the release of neurotransmitters. All these inhibited functions reduce the rate of depolarization and increase the sensitivity of neurons to small stimuli that would not elicit a response in a fully depolarized neuron. DDD is also believed to adversely affect the reproductive system by mimicking endogenous hormones and binding to the estrogen and adrogen receptors. (T10, L85)

Datos de toxicidad:

• [Toxicity Data] LD50: 113 mg/kg (Oral, Rat) (L138)